期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 57, 期 13, 页码 5686-5692出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm5004446
关键词
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资金
- MINECO [CTQ2012-32236, IT2009-0060, MAT2012-36270-C04-02]
- Junta de Andalucia Projects [P11-FQM-8136, P08-FQM-03705]
- Fondazione Cariverona (Verona, Italy)
- MIUR through FIRB [RBAP114AMK]
New long-circulating maghemite nanoparticles of 4 and 6 nm, coated with an apoferritin protein capsid, exhibit useful properties to act as magnetic resonance imaging (MRI) contrast agents. A full in vivo study of the so-called apomaghemites reveals that their long-term MRI properties are better than those of a standard superparamagnetic iron oxide (SPIO) widely used in biomedical applications. The biodistribution of apomaghemites and standard SPIO was investigated by MRI in mice at two different concentrations, 6 and 2.5 mg of Fe.kg(-1), over 60 days. Significant differences are found at low dose (2.5 mg of Fe-kg(-1)). Thus, whereas apomaghemites are active for MR bioimaging of liver for 45 days, standard SPIO is not effective beyond 7 days. On the basis of our data, we may concluded that apomaghemites can act as new long-term MRI liver contrast agents, allowing first the diagnosis of a liver pathology and then monitoring after treatment without the need for a second injection.
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