期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 56, 期 9, 页码 3742-3746出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm400236j
关键词
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资金
- Swiss National Science Foundation (SNSF Professorship) [PP00P3_123524/1]
- NCCBI PhD grant
Inhibition of coagulation factor XII (FXII) activity represents an attractive approach for the treatment and prevention of thrombotic diseases. The few existing FXII inhibitors suffer from low selectivity. Using phage display combined to rational design, we developed a potent inhibitor of FXII with more than 100-fold selectivity over related proteases. The highly selective peptide macrocycle is a promising candidate for the control of FXII activity in antithrombotic therapy and a valuable tool in hematology research.
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