期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 55, 期 7, 页码 3135-3143出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm2015952
关键词
-
资金
- National Science Fair Committee of China [NSFC 81102477]
- State Key Laboratory of Drug Research [SIMM1004KF-18]
- DENFRAME of the European Union (EC) [517711]
The results of a high-throughput screening assay using the DENV-2 replicon showed that the 2,4-diaminoquinazoline derivative 4a has a high dengue virus inhibitory activity (EC50 = 0.15 mu M). A series of 2,4-diaminoquinazoline derivatives based on 4a as a lead compound were synthesized and subjected to structure-antidengue activity relationship studies. Among the series of 2,4-diaminoquinazoline derivative probed, 4o was observed to display both the highest antiviral potency (EC50 = 2.8 nM, SI > 1000) and an excellent pharmacokinetic profile.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据