期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 55, 期 9, 页码 4511-4515出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm300215x
关键词
-
资金
- Danish Council for Independent Researchl Technology and Production [09-070364]
- Danish Council for Strategic Research [11-116196]
- Canadian Institutes of Health Research
GPR120 is a receptor of unsaturated long-chain fatty acids reported to mediate GLP-1 secretion, insulin sensitization, anti-inflammatory, and anti-obesity effects and is therefore emerging as a new potential target for treatment of type 2 diabetes and metabolic diseases. Further investigation is however hindered by the lack of suitable receptor modulators. Screening of FFA1 ligands provided a lead with moderate activity on GPR120 and moderate selectivity over FFA1. Optimization led to the discovery of the first potent and selective GPR120 agonist.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据