期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 55, 期 22, 页码 9531-9540出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm301217c
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资金
- Stiftung Rheinland-Pfalz fur Innovation
Tumor growth and metastasis are highly associated with the overexpression of protein kinases (PKs) regulating cell growth, apoptosis resistance, and prolonged cell survival. This study describes novel azaindolyl-maleimides with significant inhibition of PKs, such as VEGFR, FLT-3, and GSK-3 beta which are related to carcinogenesis. Furthermore, these compounds exhibit high kinase selectivity and potent inhibition of angiogenesis and cell proliferation, offering versatile options in cancer treatment strategies.
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