期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 55, 期 23, 页码 10776-10780出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm301262z
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资金
- Skaggs Institute for Chemical Biology at the Scripps Research Institute
- National Institutes of Health [R01-DA026625]
We challenged the performance of our previous heroin vaccine with a similar vaccine containing a more hydrolytically stable hapten analogue and a Th1 adjuvant (CpG ODN). Our results indicate that the elements of our previous vaccine are essential for its anti-heroin potency, i.e., a chemically labile hapten and an exclusively Th2 humoral response elicited by alum. Such design elements are critical for producing next-generation heroin vaccines.
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