期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 55, 期 18, 页码 7988-7997出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm301092r
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资金
- Swiss National Science Foundation [CR23I3-124753, CR22I2-140866]
- Swiss National Science Foundation (SNF) [CR22I2_140866] Funding Source: Swiss National Science Foundation (SNF)
To control the selective adhesion of human endothelial cells and human serum proteins to bioceramics of different compositions, a multifunctional ligand containing a cyclic arginine-glycine-aspartate (RGD) peptide, a tetraethylene glycol spacer, and a gallate moiety was designed, synthesized, and characterized. The binding of this ligand to alumina-based, hydroxyapatite-based, and calcium phosphate-based bioceramics was demonstrated. The conjugation of this ligand to the bioceramics induced a decrease in the nonselective and integrin-selective binding of human serum proteins, whereas the binding and adhesion of human endothelial cells was enhanced, dependent on the particular bioceramics.
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