期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 54, 期 14, 页码 5165-5173出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm2004267
关键词
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资金
- Foundation for Science and Technology (FCT), Portugal [PTDC/QUI/70359/2006, PTDC/QUI-QUI/113687/2009]
- FCT [SFRH/BD/43531/2008, SFRH/BSAB/1090/2010]
- Fundação para a Ciência e a Tecnologia [SFRH/BSAB/1090/2010] Funding Source: FCT
Two series of novel chromone derivatives were synthesized and investigated for their ability to inhibit the activity of monoamine oxidase. The SAR data indicate that chromone derivatives with substituents in position 3 of gamma-pyrone nucleus act preferably as MAO-B inhibitors, with IC50 values in the nanomolar to micromolar range. Almost all chromone 3-carboxamides display selectivity toward MAO-B. Identical substitutions on position 2 of gamma-pyrone nucleus result in complete loss of activity in both isoforms (chromones 2-12 except 3 and 5). Notably, chromone (19) exhibits an MAO-B IC50 of 63 nM, greater than 1000-fold selectivity over MAO-A, and behaves as a quasi-reversible inhibitor. Docking experiments onto the MAO binding of the most active compound highlight different interaction patterns among the isoforms A and B. The differential analysis of the solvation effects among the chromone isomers gave additional insight about the superior outline of the 3-substituted chromone derivatives.
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