期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 54, 期 7, 页码 2455-2466出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm101582z
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资金
- National Research Foundation of Korea (NRF) [NRF-2010-0015340, 2010-0022179]
- National Research Foundation of Korea [2010-0022179, 전06A1112, 2009-0066124] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Phosphatidylinositol 3-kinase alpha (P13K alpha) is an important regulator of intracellular signaling pathways, controlling remarkably diverse arrays of physiological processes. Because the P13K pathway is frequently up-regulated in human cancers, the inhibition of P13K alpha can be a promising approach to cancer therapy. In this study, we have designed and synthesized a new series of imidazo[1,2-a]pyridine derivatives as P13K alpha inhibitors through the fragment-growing strategy. By varying groups at the 3- and 6-positions of imidazo[1,2-a]pyridines, we studied the structure-activity relationships (SAR) profiles and identified a series of potent P13K alpha inhibitors. Representative derivatives showed good activity in cellular proliferation and apoptosis assays. Moreover, these inhibitors exhibited note-worthy antiangiogenic activity.
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