期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 54, 期 1, 页码 401-405出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm100968b
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资金
- CRISP
- MIUR Sostanze Naturali ed Analoghi Sintetici con Attivita Antitumorale, Rome, Italy
The finding of new PXR modulators as potential leads for treatment of human disorders characterized by dysregulation of innate immunity and with inflammation is of wide interest In this paper, we report the identification of the first example of natural marine PXR agonists, solomonsterols A and B, from a Theonella swinhoei sponge The structures were determined by interpretation of NMR and ESIMS data, and the putative binding mode to PXR has been obtained through docking calculations
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