期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 54, 期 11, 页码 3977-3981出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm200209n
关键词
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资金
- European Union
- NIH [GM25154]
- Thomas Maren grant
Aromatic amides comprising branched aliphatic carboxylic acids and 4-aminobenzenesulfonamide were evaluated for their inhibition of carbonic anhydrase (CA) isoforms. Of the most anticonvulsant-active compounds (2, 4, 13, 16, and 17), only 13, 16, and 17 were potent inhibitors of CAs VII and XIV. Compounds 9, 14, and 19 inhibited CA II, while 10 and 12 inhibited all isoforms. Structural studies suggest that differences in the active sites' hydrophobicity modulate the affinity of the inhibitors.
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