期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 54, 期 23, 页码 8224-8227出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm200984x
关键词
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Mono- and his-N-oxides of a 9-aza-anthrapyrazole derivative having two 2-(dimethylamino)ethyl appendages were prepared by using a mild oxaziridine reagent. Biochemical and cell culture assays indicate that the bis-oxide is an inactive prodrug that readily converts to the active parent molecule under hypoxic conditions that are analogous to those present within certain tumors.
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