期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 53, 期 5, 页码 2314-2318出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm901469p
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资金
- Agency for science, Technology, Technology and Research (A*STAR), Singapore
- Biomedical Research Council of Singapore [BMRC 04/1/21/19/320]
The screening of a small focused library of rhodanine derivatives as inhibitors of Bcl-2 proteins led to the discovery of two structurally related compounds with different binding profiles against the Bcl-XL and the Mcl-1 proteins. Subsequent NMR studies with Mutant proteins and in silico docking studies provide it possible rationale for the observed specificity.
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