期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 22, 页码 7113-7121出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm901017t
关键词
-
资金
- Science Foundation Ireland [SFI-CHE275]
- Consejeria de Educacion Cultura y Deporte de la Comunidad Autonoma de La Rioja
In this paper we report the synthesis of three families of new amidine-based aromatic derivatives as potential DNA minor groove binding agents for the treatment of cancer. The preparation of monoguanidine, mono-2-aminoimidazoline, and asymmetric diphenylguanidine/2-aminoimidazoline derivatives (compounds 1a-c to 8a-c) is presented. The affinity of these substrates and of a family of mono- and bis-isoureas (previously prepared in Rozas' laboratory) for DNA was evaluated by means of DNA thermal denaturation measurements. In particular, compounds 2c, 5c, 6c, 7c, and 8c were found to bind strongly both to natural DNA and to adenine-thymine oligonucleotides, showing a preference for the adenine-thymine base pair sequences.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据