期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 7, 页码 1799-1802出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm900093d
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Matrix metalloprotease 12 plays a significant role in airway inflammation and remodeling. Increased expression and production of MMP-12 have-been found in the lung of human COPD patients. MMP408 (14), a potent and selective MMP-12 inhibitor, was derived from a potent matrix metalloprotease 2 and 13 inhibitor via lead optimization and has good physical properties and bioavailability. The compound blocks rhMMP-12-induced lung inflammation in a mouse model and was advanced for further development for the treatment of COPD.
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