期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 23, 页码 7376-7379出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm900760k
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资金
- Italian Ministero dell'Istruzione, dell'Universita e della Ricerca [2006030948]
New linear and Cyclic guanidines were synthesized and tested in vitro for their antifungal activity toward clinically relevant strains of Candida species, in comparison to fluconazole. Macrocyclic Compounds showed a minimum inhibitory concentration ill the micromolar range and a biological activity profile ill some cases better than that of fluconazole. One macrocyclic derivative was also tested against Aspergillus species and showed high antifungal activity comparable to that of amphotericin B and itraconazole.
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