期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 9, 页码 2875-2879出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm9000665
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资金
- Graduiertenkolleg [GRK 1026]
We report the combination of chemical cross-linking and high-resolution mass spectrometry for analyzing conformational changes in target proteins that are induced by drug binding. With this approach conformational changes in the peroxisome proliferator-activated receptor alpha (PPAR alpha) upon binding of low-molecular weight compounds were readily detected, proving that the strategy provides a basis to efficiently characterize target protein-drug interactions.
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