期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 9, 页码 2799-2805出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm900285r
关键词
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资金
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Wellcome Trust [084655] Funding Source: Medline
Limited proteolysis coupled to matrix-assisted laser desorption/ionization (MALDI) mass spectrometric analyses can be used to screen for compounds that alter protein structure by monitoring stabilizing/destabilizing effects with respect to the rate and nature of proteolysis. When applied to prolyl hydroxylase 2, a hey enzyme involved in human oxygen sensing. the method efficiently revealed differential effects on proteolytic stability for structurally similar compounds and for different substrates.
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