期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 16, 页码 5135-5139出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm800418z
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资金
- European Association
- Algerian Government
- University of Nottingham
- Pharminox Ltd
New fluorinated 2-aryl-benzothiazoles, -benzoxazoles, and -chromen-4-ones have been synthesized and their activity against MCF-7 and MDA 468 breast cancer cell lines compared with the potent antitumor benzothiazole 5. Analogues such as 9a,b and 12a,d yielded submicromolar GI(50) values in both cell lines; however, none Of the new compounds approached 5 in terms of antitumor potency. For 5, binding to the aryl hydrocarbon receptor appeared to be necessary but not sufficient for growth inhibition.
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