期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 6, 页码 1976-1980出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm7013309
关键词
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A series of amino acid ester prodrugs of the dual VEGFR-2/FGFR-1 kinase inhibitor 1 (BMS-540215) was prepared in an effort to improve the aqueous solubility and oral bioavailability of the parent compound. These prodrugs were evaluated for their ability to liberate parent drug 1 in in vitro and in vivo systems. The L-alanine prodrug 8 (also known as brivanib alaninate/BMS-582664) was selected as a development candidate and is presently in phase II clinical trials.
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