期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 11, 页码 3061-3064出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm800180e
关键词
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The discovery of an exceptionally potent series of thrombin receptor (PAR-1) antagonists based on the natural product himbacine is described. Optimization of this series has led to the discovery of 4 (SCH 530348), a potent, oral antiplatelet agent that is currently undergoing Phase-III clinical trials for acute coronary syndrome (unstable angina/non-ST segment elevation myocardial infarction) and secondary prevention of cardiovascular events in high-risk patients.
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