期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 7, 页码 2321-2325出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm7015705
关键词
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Constrained analogues of procaine were synthesized, and their inhibiting activity against DNMT1 was tested. Among them, the most potent compound, derivative 3b, was also able to induce a recognizable demethylation of chromosomal satellite repeats in HL60 human myeloid leukemia cells and thus represents a lead compound for the development of a novel class of non-nucleoside DNMT1 inhibitors.
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