期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 19, 页码 6211-6215出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm8005004
关键词
-
资金
- Ministero dell'Universita e della Ricerca Scientifica e Tecnologica (PRIN 2006), Rome, Italy
A novel class of combretastatins, modified at A-ring or both A- and B-rings, mainly by replacement with benzofuran or benzo[b]thiophene, were synthesized. The new heterocombretastatins showed good cytotoxic activity on BMEC and H-460 cell lines. The aminocombretastatin 9f potently inhibits cell growth of BMEC and combretastatin-resistant HT-29 cell lines, with potential interest to treat colon carcinoma. Heterocombretastatins 9a,b inhibit tubulin polymerization similarly to CA-4 by having a binding to colchicine site five times stronger.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据