期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 21, 页码 6631-6634出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm8005096
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Recent studies using known Rho-associated kinase isoform 1 (ROCK1) inhibitors along with cellular and molecular biology data have revealed a pivotal role of this enzyme in many aspects of cardiovascular function. Here we report a series of ROCK 1 inhibitors which were originally derived from a dihydropyrimidinone core 1. Our efforts focused oil the optimization of dihydropyrimidine 2. which resulted in the identification of a series of dihydropyrimidines with improved pharmacokinetics and P450 properties.
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