期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 6, 页码 1577-1583出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm0708679
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资金
- NIAID NIH HHS [1R01 AI 067856-01] Funding Source: Medline
A series of methylated imidazolium salts with varying substituents on the 4 and 5 positions of the imidazole ring were synthesized. These salts were reacted with silver acetate to afford their corresponding silver N-heterocyclic carbene (NHC) complexes. These complexes were then evaluated for their stability in water as well as for their antimicrobial efficacy against a variety of bacterial strains associated with cystic fibrosis and chronic lung infections.
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