期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 19, 页码 5905-5908出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm800471h
关键词
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资金
- NIDA NIH HHS [R01 DA020669-01A1, R01 DA020669-02, R01DA020669, R01 DA020669, R01 DA020669-03] Funding Source: Medline
A series of compounds structurally related to pramipexole were designed, synthesized, and evaluated as ligands for the dopamine 3 (D-3) receptor. Compound 12 has a K-i value of 0.41 nM to D3 and a selectivity of > 30000- and 800-fold over the D-1-like and D-2 receptors, respectively. Our in vivo functional assays showed that this compound is a partial agonist at the D-3 receptor with no detectable activity at the D-2 receptor.
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