期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 5, 页码 1478-1481出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm701514k
关键词
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The structure of human aldose reductase in complex with the 2S4R stereoisomer of the potent inhibitor Fidarestat ((2S,4S)-6-fluoro-2',5'-dioxospiro-[chroman-4,4'-imidazoline]-2-carboxamide) was determined at 15 K and a resolution of 0.78 angstrom. The structure of the complex provides experimental evidence for the inhibition mechanism in which Fidarestat is initially bound neutral and then becomes negatively charged by donating the proton at the 1'-position nitrogen of the cyclic imide ring to the N epsilon 2 atom of the catalytic His 110.
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