期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 51, 期 7, 页码 2302-2306出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm701199p
关键词
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In our continuing effort to expand the SAR of the quinoline domain of dihydropyrrolopyrazole series, we have discovered compound 15d, which demonstrated the antitumor efficacy with oral bioavailability. This effort also demonstrated that the PK/PD in vivo target inhibition paradigm is an effective approach to assess potential for antitumor efficacy. The dihydropyrrolopyrazole inhibitor 15d (LY2109761) is representative of a novel series of antitumor agents.
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