期刊
JOURNAL OF MEDICAL VIROLOGY
卷 85, 期 3, 页码 483-489出版社
WILEY
DOI: 10.1002/jmv.23478
关键词
aseptic meningitis; Coxsackievirus B5 (CVB5); enterovirus; genetic characterization
类别
资金
- Shandong Provincial Natural Science Foundation, China [ZR2012HM007]
- Health Department of Shandong Province [2011QZ013, 2011HZ058]
In 2009, a major outbreak of aseptic meningitis was noted in Linyi city, Shandong province, China. From June to September 2009, a total of 2,104 cases were involved in this outbreak, and 98.6% of patients were <16 years of age. To determine the pathogen of the outbreak, 42 cerebrospinal fluid specimens collected from aseptic meningitis cases were tested for cell culture, and 17 (40.5%) enteroviruses were isolated and identified as Coxsackievirus B5 (CVB5). Homologous comparison indicated that these isolates had 07.7% nucleotide divergence with each other. Phylogenetic reconstruction showed global CVB5 could be separated into four genogroups, and all Linyi CVB5 isolates belonged to the genogroup C which had been circulating for recent 27 years in Asia and Europe. Interestingly, two distinct lineages were observed for the 17 isolates in the phylogenetic tree, indicating that at least two different transmission chains of CVB5 were responsible for this outbreak. This study showed that CVB5-associated aseptic meningitis is an emerging concern in China. J. Med. Virol. 85:483489, 2013. (c) 2012 Wiley Periodicals, Inc.
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