期刊
JOURNAL OF MEDICAL VIROLOGY
卷 83, 期 4, 页码 685-694出版社
WILEY
DOI: 10.1002/jmv.22029
关键词
GB virus C (GBV-C) HIV; diversity; genotype; recombination
类别
资金
- H.W. & J. Hector Foundation
- NIH [R21 AI081564]
Multiple genotypes of GB virus C (GBV-C)-a non-pathogenic flavivirus-have been identified to date, although they are not uniformly distributed worldwide. It has also been suggested that GBV-C genotype may play a role in modulating HIV disease; however, the prevalence and genotype distribution of GBV-C has not been adequately studied in most countries. Among 408 HIV positive subjects in Germany, 97 (23.8%) had detectable GBV-C RNA. Based on sequencing of the 5' untranslated region (5'-UTR), the GBV-C genotypes were 1 (n = 8; 8.2%), 2 (n = 81; 83.5%), and 3 (n = 2; 2.1%), as well as a unique genotype not previously reported (n = 6; 6.2%). Among 17 samples also sequenced in the envelope 2 (E2) region, 14 had concordant genotype results when comparing the 5'-UTR and E2, while evidence of intergenotypic recombination was observed among E2 sequences from 3 individuals. These results suggest that genotypic diversity and viral recombination contribute to the overall genetic variability of GBV-C. J. Med. Virol. 83:685-694, 2011. (C) 2011 Wiley-Liss, Inc.
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