期刊
JOURNAL OF MEDICAL VIROLOGY
卷 82, 期 3, 页码 460-466出版社
WILEY
DOI: 10.1002/jmv.21675
关键词
human T-lymphotropic virus 1; paraparesis; tropical spastic; genetic predisposition to disease; Peru
类别
资金
- Universidad Peruana Cayetano Heredia I internal research award
- Directorate-General for Development Cooperation of the Belgian Government
Human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a complication that affects up to 5% of HTLV-1-infected individuals. Several host genetic and viral factors have been associated with the risk of HAM/TSP. The aim of this study was to evaluate the performance of a prognostic model for HAM/TSP developed in Japan in a Peruvian population of 71 HAM/TSP patients and 94 asymptomatic carriers ACs). This model included age, proviral load (PVL), the presence of HLA-A*02 and HLA-Cw*08 alleles, SDF-1 +801, and TNF-alpha -863 polymorphisms, and viral subgroup. We describe frequencies for the four host genetic markers and demonstrate the presence of the HTLV-1 tax B subgroup in Peru. Using cross-validation, we show that the predictive ability of the prognostic model, as characterized by the area under the receiver-operating characteristic curve (AUC), does not differ from a model containing PVL only (both AUC = 0.74). We found some suggestive evidence of a protective effect of the HLA-A*02 allele but failed to replicate the associations with the other three genetic markers and with viral subgroup. A logistic model containing PVL, age, gender, and HLA-A*02 provided the best predictive ability in the Peruvian cohort AUC = 0.79). J. Med Virol. 82: 460-466, 2010. (C) 2010 Wiley-Liss, Inc.
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