期刊
JOURNAL OF MEDICAL PRIMATOLOGY
卷 38, 期 1, 页码 27-38出版社
WILEY
DOI: 10.1111/j.1600-0684.2008.00315.x
关键词
3-D structure; amino acid sequence; cDNA sequence
资金
- NIH [P01 HL028972, P51 RR013986]
- Research Facilities Improvement Program [1 C06 RR13556, 1 C06 RR15456, 1 C06 RR017515]
Carboxylesterase (CES) is predominantly responsible for the detoxification of a wide range of drugs and narcotics, and catalyze several reactions in cholesterol and fatty acid metabolism. Studies of the genetic and biochemical properties of primate CES may contribute to an improved understanding of human disease, including atherosclerosis, obesity and drug addiction, for which non-human primates serve as useful animal models. We cloned and sequenced baboon CES1 and CES2 and used in vitro and in silico methods to predict protein secondary and tertiary structures, and examined evolutionary relationships for these enzymes with other primate and mouse CES orthologs. We found that baboon CES1 and CES2 proteins retained extensive similarity with human CES1 and CES2, shared key structural features reported for human CES1, and showed family specific sequences consistent with their multimeric and monomeric subunit structures respectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据