期刊
JOURNAL OF MEDICAL PRIMATOLOGY
卷 37, 期 3, 页码 146-153出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0684.2007.00270.x
关键词
bone density; lactation; non-human primate model; parity; pregnancy; reproductive history; skeletal aging
资金
- NCRR NIH HHS [P51 RR013986-085941, P51 RR013986-076705, P51 RR013986] Funding Source: Medline
- NHLBI NIH HHS [P01 HL028972, P01 HL28972] Funding Source: Medline
- NIAMS NIH HHS [F32 AR049694-01A1, F32 AR049694, F32 AR049694-02] Funding Source: Medline
Background Little is known about the degree to which baboons, an important animal model in skeletal research, spontaneously experience age-related osteopenia and osteoporosis. Methods We measured bone mineral density (BMD) in 667 baboons, assigned T-scores to older animals based on sex-specific young adult reference groups, and compared reproductive history in older females with low BMD to those with normal BMD. Results Approximately 25% of older baboon females were osteopenic. No females or males were osteoporotic. Neither parity nor interbirth interval spine clearly distinguished low vs. normal BMD groups. Intersite correspondence in low BMD was highest between sites in the same region rather than sites of the same bone type. Conclusion As with humans, osteopenia is common among older females. The absence of osteoporotic animals may be due to colony maintenance resulting in truncation of the aged population and selection for healthier animals in the oldest ranges.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据