期刊
JOURNAL OF MEDICAL MICROBIOLOGY
卷 60, 期 1, 页码 35-45出版社
MICROBIOLOGY SOC
DOI: 10.1099/jmm.0.023465-0
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资金
- National Natural Science Foundation of China [30872789]
- Beijing Natural Science Foundation, Beijing, China [7092030]
This study aimed to evaluate the distribution of superantigen gene profiles and the presence of exfoliative toxin genes in community-acquired meticillin-resistant Staphylococcus aureus (CA-MRSA) isolated from Chinese children, and simultaneously to assess virulence gene profiles and genetic background. Of the CA-MRSA isolates, 88.9% (88/99) harboured toxin genes, with sek as the most frequent toxin gene (62.6%), followed by seq (61.6%), seb (60.6%) and sea (35.4%). The eta gene was detected only in one ST398-IVa-spa t034 strain. The sed and etd genes were not found in any of the isolates tested. A total of 38 virulence genotypes were observed, of which the genotype seb-sek-seq (27.3%, 24/88) comprised the majority, followed by sea-seb-sek-seq (18.2%, 16/88). The enterotoxin gene cluster including seg-sei-sem-sen-seo-seu predominated at a rate of 15.1%. The relationship among toxin genotypes, toxin genes encoding profiles of mobile genetic elements and genetic background was analysed. Among 66 clonal complex (CC) 59 isolates, 87.9% (58/66) were positive for toxin genes, and 75.8% (50/66) harboured the toxin gene combination seb-sek-seq. Among seb-sek-seq-positive CC59 strains, 42.0% (21/50) also carried the sea gene. CC59 corresponded exclusively to accessory gene regulator 1 (agr-1). The data presented here enhance our current knowledge on the virulence determinants of CA-MRSA.
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