期刊
JOURNAL OF MEDICAL MICROBIOLOGY
卷 57, 期 9, 页码 1051-1057出版社
SOC GENERAL MICROBIOLOGY
DOI: 10.1099/jmm.0.2008/000976-0
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资金
- Faculty Research Fund, Central Research Fund, University of London
- Nuffield Foundation and the Royal Society
Acanthamoeba granulomatous encephalitis is a rare disease that almost always proves fatal. Death occurs mainly due to neurological complications; however, the pathogenesis and pathophysiology associated with this disease remain incompletely understood. Haematogenous spread is a key step in the development of Acanthamoeba encephalitis, but it is not clear how circulating amoebae breakthrough the blood-brain barrier to gain entry into the central nervous system to produce the disease. This review of the literature describes the parasite factors and immune-mediated mechanisms involved in the blood-brain barrier dysfunction leading to neuropathogenesis.
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