期刊
JOURNAL OF MEDICAL GENETICS
卷 55, 期 11, 页码 744-752出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jmedgenet-2018-105362
关键词
genetic screening; counselling; getting research into practice; prevention; reproductive medicine
资金
- National Heart Foundation Future Leader Fellowship [100794]
- Australian National Health and Medical Research Council Principal Research Fellowship [APP1117510]
- Australian National Health and Medical Research Council Career Development Fellowship Level 1 [APP1122952]
- Australian Postgraduate Award
- Australian Genomics Health Alliance PhD top-up award
Background Preconception carrier screening (PCS) provides the potential to empower couples to make reproductive choices before having an affected child. An important question is what factors influence the decision to use or not use PCS. Methods We analysed the relationship between knowledge, attitudes and intentions to participate in PCS using logistic regression in 832 participants in Western Australia. Results Two-thirds of participants said they would take the test, with 92% of these supporting screening for diseases reducing the lifespan of children and infants. Those who had good genetic knowledge were seven times more likely to intend to use PCS (p <= 0.001), while those with high genetic knowledge were four times more likely to (p=0.002) and raised concerns such as insurance and confidentiality. Decreasing genetic knowledge correlated positively with religiosity and apprehension (p <= 0.001), which correlated negatively with intention to use PCS (p <= 0.001). Increasing genetic knowledge correlated positively with factors representing positive attitudes (p <= 0.001), which correlated positively with intention to use PCS (p <= 0.001). Many participants with good genetic knowledge nevertheless answered questions that tested understanding incorrectly. 80% of participants stated they would prefer to access the test through their general practitioners and 30% would pay up to $A200. Conclusions Knowledge is instrumental in influencing participation. Having good genetic knowledge may not be enough to understand core concepts of PCS and may impact informed decision-making. This study recommends that continuous education of health professionals and thus the community, in PCS is crucial to reduce misconceptions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据