期刊
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
卷 11, 期 1, 页码 231-272出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S021951941100396X
关键词
Scaffold; bone; reaction-diffusion system
One area of tissue engineering concerns research into alternatives for new bone formation and replacing its function. Scaffolds have been developed to meet this requirement, allowing cell migration, bone tissue growth, transport of growth factors and nutrients, and the improvement of the mechanical properties of bone. Scaffolds are made from different biomaterials and manufactured using several techniques that, in some cases, do not allow full control over the size and orientation of the pores characterizing the scaffold. A novel hypothesis that a reaction-diffusion (RD) system can be used for designing the geometrical specifications of the bone matrix is thus presented here. The hypothesis was evaluated by making simulations in two-and three-dimensional RD systems in conjunction with the biomaterial scaffold. The results showed the methodology's effectiveness in controlling features such as the percentage of porosity, size, orientation, and interconnectivity of pores in an injectable bone matrix produced by the proposed hypothesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据