期刊
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
卷 9, 期 2, 页码 243-257出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S021951940900295X
关键词
Vascular growth; remodeling; adaptation; extracellular matrix turnover; stress-strain
资金
- NHLBI NIH HHS [R01 HL064372-04, R01 HL080415-04, R01 HL086418, R01 HL064372, R01 HL080415, R01 HL086418-02] Funding Source: Medline
Arteries exhibit a remarkable ability to adapt in response to sustained alterations in hemodynamic loading as well as to disease, injury, and clinical treatment. A better understanding of such adaptations will be aided greatly by formulating, testing, and refining appropriate theoretical frameworks for modeling the biomechanics and associated mechanobiology. The goal of this brief review is to highlight some recent developments in the use of a constrained mixture theory of arterial growth and remodeling, with particular attention to the requisite constitutive relations, and to highlight future directions of needed research.
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