期刊
PEDIATRIC CLINICS OF NORTH AMERICA
卷 62, 期 5, 页码 1227-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pcl.2015.05.012
关键词
Epigenetics; Methylation; Health disparity; Social disparity; Telomere; DNA
类别
资金
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [R01 HD076592, R01HD36916, R01HD39135, R01HD40421]
- consortium of private foundations of the Fragile Families and Child Wellbeing Study
Recently, a new research agenda emphasizing interactions between social factors and health has emerged. The term social determinant of health often refers to any nonmedical factor directly influencing health. Health across the life span is strongly and adversely affected by social disadvantage. Research in epigenetics indicates that alterations in DNA methylation may provide a causal link between social adversity and health disparity. Likewise, accelerated loss of telomeres is correlated with chronic stress. Research is still required to develop an understanding of the role of epigenetics and perturbed telomere function in linking social adversity with health outcome.
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