4.4 Article

The Morris-Lecar neuron model embeds a leaky integrate-and-fire model

期刊

JOURNAL OF MATHEMATICAL BIOLOGY
卷 67, 期 2, 页码 239-259

出版社

SPRINGER
DOI: 10.1007/s00285-012-0552-7

关键词

Stochastic dynamics; Diffusions; Interspike intervals; Conditional firing probability

资金

  1. Danish Council for Independent Research\Natural Sciences
  2. Statistical and Applied Mathematical Sciences Institute, Research Triangle Park, N.C.
  3. Mathematical, Computational and Modeling Sciences Center at Arizona State University

向作者/读者索取更多资源

We show that the stochastic Morris-Lecar neuron, in a neighborhood of its stable point, can be approximated by a two-dimensional Ornstein-Uhlenbeck (OU) modulation of a constant circular motion. The associated radial OU process is an example of a leaky integrate-and-fire (LIF) model prior to firing. A new model constructed from a radial OU process together with a simple firing mechanism based on detailed Morris-Lecar firing statistics reproduces the Morris-Lecar Interspike Interval (ISI) distribution, and has the computational advantages of a LIF. The result justifies the large amount of attention paid to the LIF models.

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