期刊
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
卷 28, 期 11, 页码 1285-1290出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14767058.2014.951624
关键词
Growth restriction; hypertension; necrotizing enterocolitis; preeclampsia; prematurity
资金
- NIH/NICHD [K08HD068398-01A1]
- Harvard Catalyst, The Harvard Clinical and Translational Science Center (National Center for Research Resources)
- Harvard Catalyst, The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health) [8UL1TR000170-05]
- Harvard University
- academic health care centers
Objective: This study aimed to investigate the relationship between maternal hypertensive disease and other risk factors and the neonatal development of necrotizing enterocolitis (NEC). Methods: This was a retrospective case-control study of infants with NEC from 2008 to 2012. The primary exposure of interest was maternal hypertensive disease, which has been hypothesized to put infants at risk for NEC. Other variables collected included demographics, pregnancy complications, medications and neonatal hospital course. Data were abstracted from medical records. Results: Twenty-eight cases of singleton neonates with NEC and 81 matched controls were identified and analyzed. There was no significant difference in the primary outcome. Fetuses with an antenatal diagnosis of growth restriction were more likely to develop NEC (p = 0.008). Infants with NEC had lower median birth weight than infants without NEC (p = 0.009). Infants with NEC had more late-onset sepsis (p = 0.01) and mortality before discharge (p = 0.001). Conclusions: The factors identified by this case-control study that increased the risk of neonatal NEC included intrauterine growth restriction and lower neonatal birth weight. The primary exposure, hypertensive disease, did not show a significantly increased risk of neonatal NEC; however, there was a nearly two-fold difference observed. Our study was underpowered to detect the observed difference.
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