期刊
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
卷 27, 期 2, 页码 155-161出版社
INFORMA HEALTHCARE
DOI: 10.3109/14767058.2013.806476
关键词
Inflammatory response; intrauterine inflammation; preterm delivery
资金
- Ministry of Health, Czech Republic [NT13461-4/2012]
- Charles University in Prague
- Faculty of Medicine in Hradec Kralove, Czech Republic [PRVOUK P37/10]
- Faculty Hospital in Hradec Kralove (long-term organization development plan)
Objective: To determine the amniotic fluid nucleosome concentrations in pregnancies that are complicated by preterm prelabor rupture of membranes and their correlation to microbial invasion of the amniotic cavity (MIAC), histologic chorioamnionitis (HCA), and their association with neonatal outcomes. Methods: Eighty-nine women with singleton pregnancies were included in this study. Amniotic fluid was collected, and nucleosome concentration in the amniotic fluid was determined using enzyme-linked immunosorbent assay. Result: There were no differences observed in the amniotic fluid nucleosome concentrations in women with or without MIAC. The presence of HCA (with chorioamnionitis: median 0.5; without chorioamnionitis: median 0.21; p = 0.01) and funisitis (with funisitis: median 0.85; without funisitis: median 0.22; p = 0.0008) was associated with higher nucleosome concentrations using crude analysis; however, this was not significant after adjusting for gestational age (p = 0.12 for both). A negative correlation was observed between amniotic fluid nucleosome concentrations and gestational age (rho = -0.52; p < 0.0001). There was no association identified between amniotic fluid nucleosome concentration and neonatal morbidity. Conclusions: Amniotic fluid nucleosome concentrations remained a stable physiologic constituent in pregnancies complicated by preterm prelabor rupture of membranes, and these concentrations were gestational age dependent. Neither MIAC nor HCA significantly affected amniotic fluid nucleosome concentrations.
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