Association of maternal AGTR1 polymorphisms and preeclampsia: a systematic review and meta-analysis

Objective: Systematic review and meta-analysis to investigate the association between maternal AGTR1 gene single nucleotide polymorphisms (SNPs) and preeclampsia (PE). Methods: A systematic literature search was performed using PubMed, EMBASE, Scopus, and HuGE Literature Finder databases. The review was conducted according to PRISMA guidelines. Summary odds ratios (ORs) for the allelic and genotypic contrasts were calculated and compared to indicate the most appropriate genetic model for the polymorphism of interest. Among-study heterogeneity was assessed using the I-2 statistic and publication bias was evaluated visually using funnel plots. Results: Seven maternal SNPs investigated with PE were found, but only AGTR1 + 1166A>C accumulated sufficient evidence for meta-analysis. Summary ORs calculated from eight studies (10 populations involving 845 PE cases and 1150 controls) did not reveal an association between the + 1166A>C polymorphism and PE (allelic OR = 1.19, 95% CI: 0.96-1.47). No evidence of publication bias and among-study heterogeneity was detected. Conclusions: meta-analysis findings did not support AGTR1 + 1166A>C as a susceptibility locus for PE. Other AGTR1 SNPs require more study.