期刊
PEDIATRIC ALLERGY AND IMMUNOLOGY
卷 26, 期 1, 页码 62-72出版社
WILEY
DOI: 10.1111/pai.12321
关键词
ASTHMA; Wheezing disorders: obesity; overweight; BMI: meta-analysis; systematic literature review
资金
- Hall Dorman Research PhD Studentship
- Medical Research Council [MR/L01629X/1] Funding Source: researchfish
- MRC [MR/L01629X/1] Funding Source: UKRI
BackgroundIt has been claimed that overweight/obesity, childhood asthma and wheezing disorders are associated, although the results of observational studies have remained inconsistent. We conducted a systematic review and meta-analysis to investigate this. MethodsAn online search of published papers linking childhood asthma and wheezing with overweight/obesity up to May 2014 using EMBASE and MEDLINE medical research databases was carried out. Summary odds ratios (OR) were estimated using random-effects models. Subgroup meta-analyses were performed to assess the robustness of risk associations and between-study heterogeneity. ResultsA total of 38 studies comprising 1,411,335 participants were included in our meta-analysis. The summary ORs of underweight (<5th percentile), overweight (>85th to <95th percentile) and obesity (95th percentile) were 0.85 (95% CI: 0.75 to 0.97; p=0.02), 1.23 (95% CI: 1.17 to 1.29; p<0.001) and 1.46 (95% CI: 1.36 to 1.57, p<0.001), respectively. Heterogeneity was significant and substantial in all three weight categories, and not accounted for by pre-defined study characteristics. ConclusionOur results suggest that underweight is associated with a reduced risk of childhood asthma, and overweight and obesity are associated with an increased risk of childhood asthma. Although our findings assert that overweight/obesity and childhood asthma are associated, the causal pathway and temporal aspects of this relationship remain unanswered and deserve further epidemiological investigation.
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