Noninvasive evaluation of splanchnic tissue oxygenation using near-infrared spectroscopy in preterm neonates

Objective. aEuro integral To evaluate feasibility and safety of continuous rsSO(2) monitoring in preterm infants in the first 14 days of life. Methods. aEuro integral Preterm neonates < a parts per thousand currency sign30 weeks' gestation had a NIRS sensor placed in the left paraumbilical region within 48 h of birth. rsSO(2) was recorded every 30 s. Clinical data including pulse oximetry (SaO(2)) were recorded. Fractional tissue oxygen extraction (FTOE) was computed as follows: (SaO(2) -- rsSO(2)) xx 100/SaO(2). Results. aEuro integral Of 21 infants enrolled, 2 were excluded because of skin breakdown and missing data. Daily mean rsSO(2) values decreased over the first 9 days (p < 0.0001) followed by an increase from day 10 (D10) to D14 (p == 0.0061). rsSO(2) was lower and FTOE was higher in infants with feeding intolerance compared to those without feeding intolerance (p == 0.0043). rsSO(2) accounted for >= a parts per thousand yen99.5%% of the variance in FTOE. Two neonates with NEC had persistently low rsSO(2) with loss of variability preceded or followed by very high rsSO(2). Conclusions. aEuro integral We have reported feasibility, safety and ranges for rsSO(2) for a small number of preterm infants in the first 2 weeks of life.