Asymmetric dimethylarginine in normotensive pregnant women with isolated fetal intrauterine growth restriction: a comparison with preeclamptic women with and without intrauterine growth restriction

Patients and methods. aEuro integral The study was carried out on 54 normotensive pregnant patients with pregnancy complicated by IUGR, 35 patients with IUGR in the course of preeclampsia, 29 preeclamptic patients with appropriate-for-gestational-age weight infants and 54 healthy normotensive pregnant patients. The ADMA concentrations were evaluated using an ELISA assay. Results. aEuro integral The preeclamptic women and normotensive patients with pregnancy complicated by isolated IUGR revealed higher levels of maternal serum ADMA. The mean values of maternal serum ADMA were 0.5730 aEuroS +/-+/- aEuroS0.1769 mu mu mol/l in the P group, 0.5727 aEuroS +/-+/- aEuroS0.1756 mu mu mol/l in the PI group, 0.6129 aEuroS +/-+/- aEuroS0.1517 mu mu mol/l in the IUGR group, and 0.5017 aEuroS +/-+/- aEuroS0.1116 mu mu mol/l in the control group. The levels of ADMA were additionally higher in the patients with HELLP syndrome and in patients with pregnancy complicated by eclampsia. Conclusions. aEuro integral It seems that ADMA is an active agent not only in preeclamptic patients, but also in normotensive pregnant women with isolated fetal IUGR and could be a marker of severity of preeclampsia.