期刊
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
卷 23, 期 8, 页码 932-934出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14767050903317708
关键词
Lead; chelation; DMSA
资金
- NIEHS [R01-07821, R01-05257]
During pregnancy skeletal lead is mobilized by maternal bone turnover and can threaten fetal development. The exact strategy suggested to women of childbearing age, who were chronically exposed to lead, and, thus, have high bone lead burden, is not well established. We describe 4 years of follow-up of a 29-year-old woman with chronic lead intoxication. We (a) advised her to delay conception until 'toxicological clearance', (b) treated her with multiple courses of lead chelator, DMSA, and (c) prescribed oral calcium. Patient had low blood lead and protoporphyrin level during pregnancy until delivery. Delaying conception, lead chelation, and calcium supplementation can decrease fetal exposure.
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