期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 25, 期 6, 页码 1589-1597出版社
SPRINGER
DOI: 10.1007/s10856-014-5173-9
关键词
-
资金
- National Institute for Health Research, UK [II-FS-0909-13116]
- National Institute for Health Research [II-LA-1111-20003] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [II-FS-0909-13116, II-LA-1111-20003] Funding Source: National Institutes of Health Research (NIHR)
Adsorbents designed with porosity which allows the removal of protein bound and high molecular weight uraemic toxins may improve the effectiveness of haemodialysis treatment of chronic kidney disease (CKD). A nanoporous activated carbon monolith prototype designed for direct blood contact was first assessed for its capacity to remove albumin bound marker toxins indoxyl sulphate (IS), p-cresyl sulphate (p-CS) and high molecular weight cytokine interleukin-6 in spiked healthy donor studies. Haemodialysis patient blood samples were then used to measure the presence of these markers in pre- and post-dialysis blood and their removal by adsorbent recirculation of post-dialysis blood samples. Nanopores (20-100 nm) were necessary for marker uraemic toxin removal during in vitro studies. Limited removal of IS and p-CS occurred during haemodialysis, whereas almost complete removal occurred following perfusion through the carbon monoliths suggesting a key role for such adsorbent therapies in CKD patient care.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据