期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 24, 期 8, 页码 1885-1894出版社
SPRINGER
DOI: 10.1007/s10856-013-4957-7
关键词
-
资金
- Natural Science and Engineering Council of Canada [NSERC RGPIN 121269-09]
Hydroxyapatite/alginate nanocomposite fibrous scaffolds were fabricated via electrospinning and a novel in situ synthesis of hydroxyapatite (HAp) that mimics mineralized collagen fibrils in bone tissue. Poorly crystalline HAp nanocrystals, as confirmed by X-ray diffractometer peak approximately at 2 theta = 32A degrees and Fourier transform infrared spectroscopy spectrum with double split bands of PO4(v (4)) at 564 and 602 cm(-1), were induced to nucleate and grow at the [-COO-]-Ca2+-[-COO-] linkage sites on electrospun alginate nanofibers impregnated with PO4 (3-) ions. This novel process resulted in a uniform deposition of HAp nanocrystals on the nanofibers, overcoming the severe agglomeration of HAp nanoparticles processed by the conventional mechanical blending/electrospinning method. Preliminary in vitro cell study showed that rat calvarial osteoblasts attached more stably on the surface of the HAp/alginate scaffolds than on the pure alginate scaffold. In general, the osteoblasts were stretched and elongated into a spindle-shape on the HAp/alginate scaffolds, whereas the cells had a round-shaped morphology on the alginate scaffold. The unique nanofibrous topography combined with the hybridization of HAp and alginate can be advantageous in bone tissue regenerative medicine applications.
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