期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 25, 期 1, 页码 113-120出版社
SPRINGER
DOI: 10.1007/s10856-013-5061-8
关键词
-
资金
- National Science Foundation (NSF) [DMI-0300405, CMMI-0700139, CMMI-0925348]
The presence of a hierarchical channel network in tissue engineering scaffold is essential to construct metabolically demanding liver tissue with thick and complex structures. In this research, chitosan-gelatin (C/G) scaffolds with fine three-dimensional channels were fabricated using indirect solid freeform fabrication and freeze-drying techniques. Fabrication processes were studied to create predesigned hierarchical channel network inside C/G scaffolds and achieve desired porous structure. Static in-vitro cell culture test showed that HepG2 cells attached on both micro-pores and micro-channels in C/G scaffolds successfully. HepG2 proliferated at much higher rates on C/G scaffolds with channel network, compared with those without channels. This approach demonstrated a promising way to engineer liver scaffolds with hierarchical channel network, and may lead to the development of thick and complex liver tissue equivalent in the future.
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